Furosemide-Sensitive Na+-K+ Cotransport and Cellular Metabolism in Human Erythrocytes

Document Type

Article

Publication Date

1-10-1985

Abstract

Metabolic of human red cells with 2-deoxy-d-glucose in the presence of EGTA decreased ATP to about 4% of the initial value and increased total ouabain- and furosemide-resistant Na+ and K+ effluxes by 20% and 100%, respectively, and furosemide-sensitive Na+ and K+ effluxes by 100% and 60%, respectively. When ATP was restored, all the components of Na+ and K+ fluxes measured returned to baseline levels suggesting a metabolic dependence.

DOI

10.1016/0005-2736(85)90551-6

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