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Submissions from 2022

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IL-10 and TGF-β Increase Connexin-43 Expression and Membrane Potential of HL-1 Cardiomyocytes Coupled with RAW 264.7 Macrophages, Cora B. Cox, Mike Castro, Thomas L. Brown, and Nancy J. Bigley

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Motoneuron Excitability Dysfunction in ALS: Pseudo-Mystery or Authentic Conundrum?, Sherif M. Elbasiouny

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Non-Invasive Transcutaneous Spinal DC Stimulation as a Neurorehabilitation ALS Therapy in Awake G93A Mice: The First Step to Clinical Translation, Morgan M. Highlander and Sherif M. Elbasiouny

Diverging from the Norm: Reevaluating What Miniature Excitatory Postsynaptic Currents Tell Us about Homeostatic Synaptic Plasticity, Andrew G. Koesters, Mark M. Rich, and Kathrin L. Engisch

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Suppression of Store-operated Calcium Entry Channels and Cytokine Release by Cannabinoids, J. Ashot Kozak

Imbalanced Subthreshold Currents Following Sepsis and Chemotherapy: A Shared Mechanism Offering a New Therapeutic Target?, Mark M. Rich, Stephen N. Housley, Paul Nardelli, Randall K. Powers, and Timothy C. Cope

TRPM7 Kinase Inactivation Results in Macrophage Alkalinization and Increased Phagocytic Activity, Jananie Rockwood, Pavani Beesetty, Taku Kaitsuka, Masayuki Matsushita, and J. Ashot Kozak

Submissions from 2021

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NSAIDs Naproxen, Ibuprofen, Salicylate, and Aspirin Inhibit TRPM7 Channels by Cytosolic Acidification, Rikki Chokshi, Orville Bennett, Tetyana Zhelay, and J. Ashot Kozak

In-Silico Development and Assessment of a Kalman Filter Motor Decoder for Prosthetic Hand Control, Mai Gamal, Mohamed H. Mousa, Seif Eldawlatly, and Sherif M. Elbasiouny

TRPM7 Permeant Divalent Metal Cytotoxicity During Magnesium Depletion and Loading, Alayna A. Mellott, Jananie Rockwood, Charles T. Luu, and J. Ashot Kozak

Estimating the Effects of Slicing on the Electrophysiological Properties of Spinal Motoneurons Under Normal and Disease Conditions, Mohamed H. Mousa and Sherif M. Elbasiouny

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The Mechanism Underlying Transient Weakness in Myotonia Congenita, Jessica H. Myers, Kirsten Denman, Chris DuPont, Ahmed A. Hawash, Kevin R. Novak, Andrew Koesters, Manfred Grabner, Anamika Dayal, Andrew A. Voss, and Mark M. Rich

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A Mouse Model of Huntington’s Disease Shows Altered Ultrastructure of Transverse Tubules in Skeletal Muscle Fibers, Shannon H. Romer, Sabrina Metzger, Kristiana Peraza, Matthew C. Wright, D. Scott Jobe, Long-Sheng Song, Mark M. Rich, Brent D. Foy, Robert J. Talmadge, and Andrew A. Voss

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Placenta-Specific Slc38a2/SNAT2 Knockdown Causes Fetal Growth Restriction in Mice, Owen R. Vaughan, Katarzyna Maksym, Elena Silva, Kenneth Barentsen, Russel V. Anthony, Sara L. Hillman, Thomas L. Brown, Rebecca Spencer, Anna L. David, Fredrick J. Rosario, Theresa L. Powell, and Thomas Jansson

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Current State of Preeclampsia Mouse Models: Approaches, Relevance, and Standardization, Christopher A. Waker, Melissa R. Kaufman, and Thomas L. Brown

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The Role of Action Potential Waveform in Failure of Excitation Contraction Coupling, Xueyong Wang, Murad Nawaz, Steve R.A. Burke, Roger Bannister, Brent D. Foy, Andrew A. Voss, and Mark M. Rich

Submissions from 2020

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Effects of Neuronic Shutter Observed in the EEG Alpha Rhythm, Kevin E. Alexander, Justin R. Estepp, and Sherif M. Elbasiouny

Phagocytic Activity of Splenic Macrophages Is Enhanced and Accompanied by Cytosolic Alkalinization in TRPM7 Kinase-Dead Mice, Pavani Beesetty, Jananie Rockwood, Taku Kaitsuka, Tetyana Zhelay, Siham Hourani, Masayuki Matsushita, and J. Ashot Kozak

Neuromuscular Junction Transmission Failure Is a Late Phenotype in Aging Mice, Deepti Chugh, Chitra C. Iyer, Xueyong Wang, Prameela Bobbili, Mark M. Rich, and W. David Arnold

Divergent Synaptic Scaling of Miniature EPSCs following Activity Blockade in Dissociated Neuronal Cultures, Amanda L. Hanes, Andrew G. Koesters, Ming-fai Fong, Haider F. Altimimi, David Stellwagen, Peter Wenner, and Kathrin L. Engisch

Meta-analysis of biological variables’ impact on spinal motoneuron electrophysiology data, Morgan M. Highlander, John M. Allen, and Sherif M. Elbasiouny

Chronic Defects in Intraspinal Mechanisms of Spike Encoding by Spinal Motoneurons Following Chemotherapy, Stephen N. Housley, Paul Nardelli, Randal K. Powers, Mark M. Rich, and Timothy C. Cope

TRPM7 Channel Activity in Jurkat T Lymphocytes During Magnesium Depletion and Loading: Implications for Divalent Metal Entry and Cytotoxicity, Alayna Mellott, Jananie Rockwood, Tetyana Zhelay, Charles Tuan Luu, Taku Kaitsuka, and J. Ashot Kozak

Central Role of Subthreshold Currents in Myotonia, Sabrina Metzger, Chris Dupont, Andrew A. Voss, and Mark M. Rich

Central Role of Subthreshold Currents in Myotonia, Sabrina Metzger, Chris Dupont, Andrew A. Voss, and Mark M. Rich

Dendritic Distributions of L-type Ca2+ and SKL Channels in Spinal Motoneurons: A Simulation Study, Mohamed H. Mousa and Sherif M. Elbasiouny

Multi-Walled Carbon Nanotube Carpets as Scaffolds for u87mg Glioblastoma Multiforme Cell Growth, Soham D. Parikh, Soham Dave, Luping Huang, Wenhu Wang, Sharmila M. Mukhopadhyay, and Debra A. Mayes

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Effects of TRPM7 Kinase Inactivation in Macrophages, Jananie Rockwood, Pavani Beesetty, Masayuki Matsushita, and J. Ashot Kozak

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Depressed Neuromuscular Transmission Causes Weakness in Mice Lacking BK Potassium Channels, Xueyong Wang, Steven R.A. Burke, Robert J. Talmadge, Andrew A. Voss, and Mark M. Rich

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Depressed Neuromuscular Transmission Causes Weakness in Mice Lacking BK Potassium Channels, Xueyong Wang, Steven R.A. Burke, Robert J. Talmadge, Andrew A. Voss, and Mark M. Rich

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COVID 19 What You Need to Know, Dawn P. Wooley, Giancarlo Mariani, Craig Woolley, and Laura M. Luehrmann

Submissions from 2019

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Removal of the Potassium Chloride Co-Transporter from the Somatodendritic Membrane of Axotomized Motoneurons Is Independent of BDNF/TrkB Signaling But Is Controlled by Neuromuscular Innervation, Erica Tracey Akhter, Ronald W. Griffith, Arthur W. English, and Francisco J. Alvarez

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Trophoblast-Specific Expression of Hif-1α Results in Preeclampsia-Like Symptoms and Fetal Growth Restriction, Renee E. Albers, Melissa R. Kaufman, Bryony V. Natale, Chanel Keoni, Kashmira Kulkarni-Datar, Sarah Min, Clintoria R. Williams, David R.C. Natale, and Thomas L. Brown

A Motor Physiology Recurrent Topic: Simplify Assumptions to Gain Extra Insight, Francisco J. Alvarez

Treatment of Myotonia Congenita With Retigabine in Mice, Chris Dupont, Kirsten S. Denman, Ahmed A. Hawash, Andrew A. Voss, and Mark M. Rich

Automated Cell-Type Classification and Death-Detection of Spinal Motoneurons, Mai Gamal, Mohamed H. Mousa, Seif Eldawlatly, and Sherif M. Elbasiouny

Genetic and Pharmacological Inactivation of Apical NA+-K+-2cl− Cotransporter 1 in Choroid Plexus Epithelial Cells Reveals the Physiological Function of the Cotransporter, Jeannine MC Gregoriades, Aaron Madaris, Francisco J. Alvarez, and Francisco J. Alvarez-Leefmans

Open-Label Trial of Ranolazine for the Treatment of Paramyotonia Congenita, Samantha Lorusso, David Kline, Amy Bartlett, Miriam Freimer, Julie Agriesti, Ahmed A. Hawash, Mark M. Rich, John T. Kissel, and W. David Arnold

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The Mechanistic Basis for Successful Spinal Cord Stimulation to Generate Steady Motor Outputs, Amr A. Mahrous, Mohamed H. Mousa, and Sherif M. Elbasiouny

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Spinal Motor Circuit Synaptic Plasticity after Peripheral Nerve Injury Depends on Microglia Activation and a CCR2 Mechanism, Travis M. Rotterman, Erica T. Akhter, Alicia R. Lane, Kathryn P. MacPherson, Violet V. Garcia, Malu G. Tansey, and Francisco J. Alvarez

Calcium Imaging of Parvalbumin Neurons in the Dorsal Root Ganglia, Marie C. Walters, Martha Sonner, Jessica H. Myers, and David R. Ladle

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Initial Characterization of the Indole-3-Carboxamide Bic-154 as a Fast Onset and Reversible ORAI Channel Blocker, Tetyana Zhelay, Kalina Szteyn, Elisa Liardo, Jae Eun Cheong, Steffi Koerner, Anil Ekkati, Lijun Sun, and J. Ashot Kozak

Submissions from 2018

Protect NIH's DNA Advisory Committee, Zach N. Adelman, Lorraine M. Albritton, Kathleen Boris-Lawrie, Michael J. Buchmeier, Paula Cannon, Mildred Cho, David DiGiusto, J Kevin Donahue, Howard J. Federoff, Marie-Louise Hammarskjold, Angelica D. Hardison, Benhur Lee, Dean Anthony Lee, Matthew H. Porteus, Lainie Friedman Ross, Susan R. Ross, Dawn P. Wooley, and Laurie Zoloth

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TGF-β induces Smad2 phosphorylation, ARE induction, and trophoblast differentiation, Renee E. Albers, Kaisa Selesniemi, David R.C. Natale, and Thomas L. Brown

Gestational differences in murine placenta: Glycolytic metabolism and pregnancy parameters, Renee E. Albers, Christopher A. Waker, Chanel Keoni, Melissa R. Kaufman, Michael A. Bottomley, Sarah Min, David R. Natale, and Thomas L. Brown

The effects of model composition design choices on high-fidelity simulations of motoneuron recruitment and firing behaviors, John M. Allen and Sherif M. Elbasiouny

Spinal Interneurons “à La Carte”, Francisco J. Alvarez

N-Acetylcysteine Modulation of Mitochondrial Respiration and Blood Brain Barrier Permeability Is Time Dependent and Cell Type Specific, Alim S El Amouri, Christopher A. Waker, Luping Huang, Cameron L. Smith, and Debra A. Mayes

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Inactivation of TRPM7 Kinase in Mice Results in Enlarged Spleens, Reduced T-Cell Proliferation and Diminished Store-Operated Calcium Entry, Pavani Beesetty, Krystyna Blanka Wieczerzak, Jennifer Gibson, Taku Kaitsuka, Charles Tuan Luu, Masayuki Matsushita, and J. Ashot Kozak

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The vulnerability of spinal motoneurons and soma size plasticity in a mouse model of amyotrophic lateral sclerosis, S. Shekar Dukkipati, Teresa L. Garrett, and Sherif M. Elbasiouny

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Gender- and Region-Specific Changes in Estrogen Signaling in Aging Rat Brain Mitochondria, Christopher M. Evola, Tanner L. Hudson, Luping Huang, Adrian M. Corbett, and Debra A. Mayes

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Preventing Acute Asthmatic Symptoms by Targeting a Neuronal Mechanism Involving Carotid Body Lysophosphatidic Acid Receptors, Nicholas G. Jendzjowsky, Arijit Roy, Nicole O. Barioni, Margaret M. Kelly, Francis HY Green, Christopher N. Wyatt, Richard L. Pye, Luana Tenorio Lopes, and Richard A. Wilson

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Modulation of SK channels regulates locomotor alternating bursting activity in the functionally-mature spinal cord, Amr A. Mahrou and Sherif M. Elbasiouny

Activation of TRPV4 Stimulates Transepithelial Ion Flux in a Porcine Choroid Plexus Cell Line, Daniel Preston, Stefanie Simpson, Dan R. Halm, Alexandra Hochestetler, Christian Schwerk, Horst Schroten, and Bonnie L. Blazer-Yost

High Fat Feeding in Rats Alters Respiratory Parameters by a Mechanism That Is Unlikely to Be Mediated by Carotid Body Type I Cells, Ryan J. Rakoczy, Richard L. Pye, Tariq Hasan Fayyad, Joseph Michael Santin, Barbara L. Barr, and Christopher N. Wyatt

Facilitation of Antagonist Motor Output Through Short-Latency Sensory Pathways During Postnatal Development in the Mouse, Patrick M. Sonner and David R. Ladle

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Muscle Nicotinic Acetylcholine Receptors May Mediate Trans-Synaptic Signaling at the Mouse Neuromuscular Junction, Xueyong Wang, J. Michael McIntosh, and Mark M. Rich

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Muscle Nicotinic Acetylcholine Receptors May Mediate Trans-Synaptic Signaling at the Mouse Neuromuscular Junction, Xueyong Wang, J. Michael McIntosh, and Mark M. Rich

Homeostatic Synaptic Plasticity at the Neuromuscular Junction in Myasthenia Gravis, Xueyong Wang and Mark M. Rich

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TRPM7 Current Inactivation: Evidence for Inside-Out Signaling, Tetyana Zhelay and J. Ashot Kozak

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Depletion of Plasma Membrane–Associated Phosphoinositides Mimics Inhibition of TRPM7 Channels by Cytosolic Mg2+, Spermine, and pH, Tetyana Zhelay, Krystyna Blanka Wieczerzak, Pavani Beesetty, Gerald M. Alter, Masayuki Matsushita, and J. Ashot Kozak

Submissions from 2017

Gephyrin and the Regulation of Synaptic Strength and Dynamics at Glycinergic Inhibitory Synapses, Francisco J. Alvarez

Open-Label Trial of Ranolazine for the Treatment of Myotonia Congenita, W. David Arnold, David Kline, Alan Sanderson, Ahmed A. Hawash, Amy Bartlett, Kevin R. Novak, Mark M. Rich, and John T. Kissel

Ventilatory and Chemoreceptor Responses to Hypercapnia in Neonatal Rats Chronically Exposed to Moderate Hyperoxia, Ryan W. Bavis, Ke-yong Li, Kathryn J. DeAngelis, Ryan J. March, Josefine A. Wallace, Sarah Logan, and Robert W. Putnam

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Regulation of TRPM7 by Cytosolic Mg2+ and pH: Insights from VSP Expression, Pavani Beesetty, Krystyna Blanka Wieczerzak, Tatyana Zhelay, Taku Kaitsuka, Masayuki Matsushita, and J. Ashot Kozak

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Experimental design and data analysis issues contribute to inconsistent results of C-bouton changes in amyotrophic lateral sclerosis, S. Shekar Dukkipati, Aouatef Chihi, Yiwen Wang, and Sherif M. Elbasiouny

Cross-Disciplinary Medical Advances with Neuroengineering: Challenges Spur Development of Unique Rehabilitative and Therapeutic Interventions, Sherif Elbasiouny

Characterization of Calbindin D28k Expressing Interneurons in the Ventral Horn of the Mouse Spinal Cord, Taylor L. Floyd, Yiyun Dai, and David R. Ladle

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Survival and Growth of C57BL/6J Mice Lacking the BK Channel, Kcnma1: Lower Adult Body Weight Occurs Together with Higher Body Fat, Susan T. Halm, Michael A. Bottomley, Mohammed M. Almutairi, Mauricio Di Fulvio, and Dan R. Halm

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Inhibiting Persistent Inward Sodium Currents Prevents Myotonia, Ahmed A. Hawash, Andrew A. Voss, and Mark M. Rich

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Depressed Synaptic Transmission and Reduced Vesicle Release Sites in Huntington's Disease Neuromuscular Junctions, Ahmad Khedraki, Eric J. Reed, Shannon H. Romer, Qingbo Wang, William Romine, Mark M. Rich, Robert J. Talmadge, and Andrew A. Voss

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The Neuronal K+CL− Co-Transporter 2 (Slc12a5) Modulates Insulin Secretion, Shams Kursan, Timothy S. McMillen, Pavani Beesetty, Eduardo Dias-Junior, Mohammed M. Almutairi, Abu A. Sajib, J. Ashot Kozak, Lydia Aguilar-Bryan, and Mauicio Di Fulvio

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SK channel inhibition mediates the initiation and amplitude modulation of synchronized burst firing in the spinal cord, Amr A. Mahrous and Sherif M. Elbasiouny

Simulation of dendritic L-type ca channels' warm-up phenomenon in spinal motoneurons, Mohamed H. Mousa, Ahmed H. Kandil, and Sherif M. Elbasiouny

Increasing Motor Neuron Excitability to Treat Weakness in Sepsis, Paul Nardelli, Randall Powers, Tim C. Cope, and Mark M. Rich

Dicer Maintains the Identity and Function of Proprioceptive Sensory Neurons, Sean M. O'Toole, Monica M. Ferrer, Jennifer Mekonnen, Haihan Zhang, Yasuyuki Shima, David R. Ladle, and Sacha B. Nelson

Refining Forelimb Asymmetry Analysis: Correlation with Montoya Staircase Contralateral Function Post-stroke, Moner A. Ragas, Devipriyanka Nagarajan, and Adrian M. Corbett

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Distinct Roles for Motor Neuron Autophagy Early and Late in the sod1g93a Mouse Model of Als, Noam D. Rudnick, Christopher J. Griffey, Paolo Guarnieri, Valeria Gerbino, Xueyong Wang, Jason A. Piersaint, Juan Carlos Tapia, Mark M. Rich, and Tom Maniatis

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VGLUT1 Synapses and P-Boutons on Regenerating Motoneurons After Nerve Crush, Adam J. Schultz, Travis M. Rotterman, Anirudh Dwarakanath, and Francisco J. Alvarez

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Analysis of Proprioceptive Sensory Innervation of the Mouse Soleus: A Whole-Mount Muscle Approach, Martha Jean Sonner, Marie C. Walters, and David R. Ladle

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Mixed-mode Oscillations in Pyramidal Neurons Under Antiepileptic Drug Conditions, Babak V-Ghaffari, M. Kouhnavard, and Sherif M. Elbasiouny

AMPK Knockdown in Placental Labyrinthine Progenitor Cells Results in Restriction of Critical Energy Resources and Terminal Differentiation Failure, Christopher A. Waker, Renee E. Albers, Richard L. Pye, Savannah R. Doliboa, Christopher N. Wyatt, Thomas L. Brown, and Debra A. Mayes

AMPK Knockdown in Placental Labyrinthine Progenitor Cells Results in Restriction of Critical Energy Resources and Terminal Differentiation Failure, Christopher A. Waker, Renee E. Albers, Richard L. Pye, Savannah R. Doliboa, Christopher N. Wyatt, Thomas L. Brown, and Debra A. Mayes

A Directed Evolution Approach to Select for Novel Adeno-Associated Virus Capsids on an HIV-1 Producer T Cell Line, Dawn P. Wooley, Priyanka Sharma, John R. Weinstein, Poornima Kotha Lakshmi Narayan, David V. Schaffer, and Katherine J.D.A. Excoffon

Duplex Quantitative Polymerase Chain Reaction Assay for Detection of Adenoviral and Lentiviral Vectors, Dawn P. Wooley and Swathee Vasanth

Submissions from 2016

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Mitogenic Activation and Proliferation of T Lymphocytes in TRPM7 Kinase-Dead Mutant Mice, Pavani Beesetty, Masayuki Matsushita, and J. Ashot Kozak

Mitogenic Activation and Proliferation of T Lymphocytes in TRPM7 Kinase-Dead Mutant Mice, Pavani Beesetty, Masayuki Matsushita, and J. Ashot Kozak

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Rapid Quantification of Mitogen-induced Blastogenesis in T Lymphocytes for Identifying Immunomodulatory Drugs, Jennifer Gibson, Pavani Beesetty, Sulentic Courtney, and J. Ashot Kozak

Physiologic Influences of Transepithelial K+ Secretion, Dan R. Halm

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Synapse Formation in Monosynaptic Sensory–Motor Connections Is Regulated by Presynaptic Rho GTPase Cdc42, Fumiyasu Imai, David R. Ladle, Jennifer R. Leslie, Xin Duan, Tilat A. Rizvi, Georgianne M. Ciraolo, Yi Zheng, and Yutaka Yoshida

Anatomical and Functional Connections between the Locus Coeruleus and the Nucleus Tractus Solitarius in Neonatal Rats, Luana Tenorio Lopes, Luis Gustavo Alexandre Patrone, K. -Y. Li, Ann N. Imber, Cathy D. Graham, Luciane H. Gargaglioni, and Robert W. Putnam

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Reduced Motor Neuron Excitability is an Important Contributor to Weakness in a Rat Model of Sepsis, Paul Nardelli, Jacob A. Vincent, Randall K. Powers, Timothy C. Cope, and Mark M. Rich

Appropriate Timing of Fluoxetine and Statin Administration Reduces the Risk of Secondary Hemorrhagic Infarct After Ischemic Stroke, Moner A. Ragas, Maria Helen Harley Balch, Danny Wright, Amber Lee Hensley, Kenny Reynolds, Bryce Kerr, and Adrian M. Corbett

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Risks Associated With Lentiviral Vector Exposures and Prevention Strategies, Ryan Schlimgen, John Howard, Dawn P. Wooley, Maureen Thompson, Lindsey Baden, Otto Yang, David Christiani, Gustavo Mostoslavsky, David Diamond, Elizabeth Gilman, Karen Byers, Thomas Winters, Jeffrey A. Gelfand, Gary Fujimoto, T Warner Hudson, and Jatin M. Vyas

Id2 Mediates Differentiation of Labyrinthine Placental Progenitor Cell Line, SM10, Kaisa Selesniemi, Renee E. Albers, and Thomas L. Brown

Role of Primary Afferents in the Developmental Regulation of Motor Axon Synapse Numbers on Renshaw Cells, Valerie C. Siembab, Laura Gomez-Perez, Travis M. Rotterman, Neil A. Shneider, and Francisco J. Alvarez

Adrenaline Release Evokes Hyperpnoea and an Increase in Ventilatory CO2 Sensitivity during Hypoglycaemia: A Role for the Carotid Body, Emma L. Thompson, Clare J. Ray, Andrew P. Holmes, Richard L. Pye, Christopher N. Wyatt, Andrew M. Coney, and Prem Kumar

Microglial Acid Sensing Regulates Carbon Dioxide-Evoked Fear, Lauren Larke Vollmer, Sriparna Ghosal, Jennifer L. McGuire, Rebecca L. Ahlbrand, Ke-yong Li, Joseph Michael Santin, Christine A. Ratliff-Rang, Luis Gustavo Alexandre Patrone, Jennifer Rush, Ian P. Lewkowich, James P. Herman, Robert W. Putnam, and Renu Sah

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Reversible Recruitment of a Homeostatic Reserve Pool of Synaptic Vesicles Underlies Rapid Homeostatic Plasticity of Quantal Content, Xueyong Wang, Martin J. Pinter, and Mark M. Rich

Submissions from 2015

Placental-Specific Hypoxia Inducible Factor-1 alpha as a Model of Preeclampsia, Renee E. Albers, Melissa R. Kaufman, Chanel Keoni, Martha Hughes, Bryony Natale, David Natale, and Thomas L. Brown